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  • The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in older adults with a body mass index (BMI) greater than 27, provided that they also are afflicted by weight-related health issues such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure levels).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder and as an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle which includes a reduced-calorie diet and exercise, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes showed that patients had an average weight loss of 4.1% rather than participants have been given placebos) after a 12- month period, while another study involving patients with diabetes type 2 had a normal weight loss of 2% over treatment with placebo at twelve months.

    Using two separate drugs to shed pounds can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it one should err along the side of caution and let the FDA do its job and demand some research be done so that the public is aware of the side effects and hazards of the medications before we bring them. Keep in mind that drug companies have been in business to generate money and that they would say everything to keep people on the medications.

    Researchers discovered that participants taking this drug for a year, lost excess weight within a month and have kept the body weight off throughout the 56 weeks from the study. Contrave is really a combination from the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs that are made up of several active ingredient, that might make them more efficient and safer.

    Combo-pilling is the newest fad or also the newest ahead under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is becoming popular will be the fact that by right now there are no long term prescription slimming capsules that have been approved by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA.

    Seizures really are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug could also raise blood pressure level and heartbeat, and really should not be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure and pulse rate and must not be used in patients with uncontrolled high blood pressure level, along with by you aren't heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients using a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.

    To keep up with the most current articles from Wendi, the Indiana Addiction Recovery Examiner, click the subscribe link on top of the page to get email notification when new submissions are published. Please leave a comment for almost any article.